Explain through concepts and technologies common to Cellular and Molecular Biology, Biochemistry and Genetics how the cells develop, propagate, communicate and control their activity. How do they deviate from this pattern of behaviour and what are the clinical consequences of these deviations for cell survival as a unit and the individual as a whole. To apply / choose appropriate technologies to study cellular functions. Integrate knowledge. Present and interpret experimental results and evaluate the possibilities and implications of the diagnoses.
Apply and integrate the knowledge gained in: the understanding of the molecular mechanisms of disease, the interpretation and solution of problems related to such knowledge. Develop the capacity for self-learning, research and information selection.
METABOLIC CHARACTERISTICS OF DIFFERENT TISSUES
General organization of cellular metabolism
General principles of metabolism
Major metabolic pathways
Major catabolic pathways
Hierarchy to store and burn energy substrates
General principles of metabolic management at the level of the organism
General principles of metabolic management at the cellular level
General principles of metabolic management at the tissue level
Cellular processes in the hepatocyte and adipocyte
Cellular processes in the neuron and myocyte
Regulation and control of cellular homeostasis
General principles of cell communication
Revisiting enzyme kinetics
Alosteria and control
Enzymes, engines and decision-makers
Integration of signalling cascades
MECHANISMS OF CELL DIFFERENTIATION
Cellular mechanisms of development
Molecular mechanisms of development
Cellular and Molecular Biology; Biochemistry
Generic skills to reach
. Competence in analysis and synthesis; . Competence to solve problems; . Valuing diversity and multiculturalism; . Competence in applying theoretical knowledge in practice; . Competence in oral and written communication; . Capacity of decision; . Competence for working in group; . Competence to communicate with people who are not experts in the field; . Competence in understanding the language of other specialists; . Ethical commitment; . Competence in autonomous learning; . Research skills; (by decreasing order of importance)
Teaching hours per semester
total of teaching hours
Sseminar or study visit
Bibliography of reference
Gilbert, S.F. ?Biologia do Desenvolvimento?, Fundação Calouste Gulbenkian, 2008
Koolman, J., Röhm, K.H. ?Color Atlas of Biochemistry?, Thieme, 1996.
Cunha, R.A. ?Regulação Bioquímica?, Cap. 17 in ?Bioquímica ? Organização Molecular da Vida? (Quintas, A., Freire, A.P., Halpern, M.J.), 2009.
Traditional lectures, where it is the sole responsibility of the teacher to present general concepts of regulation and control within a cell, a tissue and an organism.
Theoretical and practical lessons in the form of oriented seminars with presentations by students of proposed topics, followed by a period of discussion among students, coordinated by the teacher; these contacts are terminated by a comment and questions from the teacher.