Biophysics - EB3

Ano letivo: 2014-2015
Specification sheet

Specific details
course codecycle os studiesacademic semestercredits ECTSteaching language

Learning goals
Biophysics, interdisciplinary science, uses the laws of physics and mathematical methods to explain biological phenomena. The development of methods to analyse and measure physiologic parameters is one of its best known applications. There are several medical areas where physics methods are obvious such cardiology, ophthalmology, orthopaedics, imaging, nuclear medicine, etc.
The goal is to give a general view of Biophysics applications in health sciences, covering different subjects, such as transport mechanisms, bioelectricity, solid state, fluids, radiation and thermodynamics. Special attention will be paid on:
-molecular transport across cellular membranes
-distribution of dipoles and its relation to signal acquisition and clinical interpretation
-physical properties of biological materials and their relation to structure of matter
-fluids behaviour and its relation to pathological situations
-harmful consequences of radiation and their effects, dose limits and radioprotection.
1st day - 13:00 ? 20:00 (M Filomena Botelho, M Morgado,M Patrício, F Caramelo, R Bernardes)
Introduction to Biophysics Course
Optical Radiation Protection
Applications with the finite element method
Critical analysis of papers

2nd day - 13:00 ? 20:00 (M Filomena Botelho, F Caramelo, R Bernardes)
Ionizing radiation protection
Critical analysis of papers

3rd day - 13:00 ? 20:00 (M José Ribeiro, M Filomena Botelho, F Caramelo, R Bernardes)
Interfaces Brain-Computer
Critical analysis of papers

4th day - 13:00 ? 20:00 (A Dourado, R Bernardes, F Caramelo)
Systems and Intelligent Data Analysis in Medicine
Group work: Laboratory component of computer
Elaboration and discussion of report

5th day - 13:00 ? 20:00 (A Paixão, N Ferreira, F Caramelo, M Filomena Botelho)
Structure of matter
laboratory applications
Elaboration and discussion of report
Basic knowledge and competences in Biophysics and applied Physics. The course can be held in both Portuguese or English
Generic skills to reach
. Competence in analysis and synthesis;
. Competence to solve problems;
. Critical thinking;
. Competence in understanding the language of other specialists;
. Competence in autonomous learning;
. Competence for working in group;
. Competence in working in interdisciplinary teams;
. Planning and managing;
. Research skills;
(by decreasing order of importance)
Teaching hours per semester
tutorial guidance20
total of teaching hours35

Sseminar or study visit30 %
Exam30 %
Otheranálise crítica de artigos científicos: 40 %

Bibliography of reference
1. ?Intermediate Physics for Medicine and Biology?, 2cd Edition, Russel Hobbie; John Wiley and Sons
2. ?Radiobiology for the Radiologist?, 5th Edition, Eric Hall; Lippincott Williams & Wilkins
3. ?Mathematical Physiology?, James Keener, James Sneyd, Springer
4. ?Éléments de biophysique?, vol I e II, F. Grémy, J. Perrin, Flammarion
5. Biophysics. Searching for principles. William Bialek. Princeton University Press. USA
Teaching method
Lectures will be given by a group of leading experts in Biophysics. Beyond that, computational simulations in laboratory environment and small group discussions will allow the PhD students to brainstorm around new research ideas and develop new research projects, always with a face to face interaction with the faculty members. Critical analysis of published research articles will also be performed. Continuous evaluation of the students will be performed during course. There will also be a theoretical evaluation.
Resources used
Acesso a bases de dados bibliográficos, ligação à Internet. Sala de Computadores