Introduction to Nuclear Chemistry and Radiopharmacy - EB

Ano letivo: 2015-2016
Specification sheet

Specific details
course codecycle os studiesacademic semestercredits ECTSteaching language

Learning goals
Knowledge of laws on radio pharmacy, namely the regulations on radio-protection, and GMP, GLP and ICRP60 laws.
Basic equipment of a radio pharmacy (clinical/research) and its quality control.
Production, detection and quality control of radionuclides and radiopharmaceuticals.
Radiomarking processes and their quality control.
Radiopharmacology applications in biomedicine (clinical or research).
Introduction to Nuclear Chemistry. Radionuclides' prodcution. Nuclear Medicine. Detection and quantification techniques. Particle accelerators.
Introduction to Radiopharmacology and its history.
Radiopharmacology equipment and laboratory.
Radiopharmaceuticals' characteristics. Basic methods of radioactive marking. Design and industrial production of radiopharmaceuticals.
Quality control. Storage and management of residues and waste.
Brief introduction to practical radio pharmacology.
Brief review of radiopharmaceutcial localisation mechanisms.
Radionuclides in pharmacology: pharmacokinetics and and pharmacodynamics. Biodistribution. Binding assays.
Introduction to the use of radiotracers/radiopharmaceuticals in Nuclear Medicine.
Introductio to auto-radiography.
Radionuclides' applications in Space Biology and Medicine.
Radiopharmacology laws, regulations and practice.
Anatomy and Histology; General Chemistry; Molecular and Cellular Biology; Biochemistry; Physiology I; Radiations in Biomedicine.
Generic skills to reach
. Competence in analysis and synthesis;
. Competence to solve problems;
. Competence for working in group;
. Competence in working in interdisciplinary teams;
. Competence in applying theoretical knowledge in practice;
. Competence in oral and written communication;
. Competence to communicate with people who are not experts in the field;
. Competence in understanding the language of other specialists;
. Adaptability to new situations;
. Quality concerns;
(by decreasing order of importance)
Teaching hours per semester
theory-practical classes28
laboratory classes16
tutorial guidance3
total of teaching hours50

Sseminar or study visit30 %
Laboratory or field work20 %
Exam50 %

Bibliography of reference
Bushberg JT, Seibert JA, Leidnoldt EM, Boone JM The essential physics of medical imaging, Lippincott Williams & Wilkins, NY (2nd ed.)
Hendee WR & Ritenou ER Medical imaging physics, Wiley-Liss, NY (4th ed., 2002)
Gopal B Saha Fundamentals of Nuclear Pharmacy, Springer, NY (5th ed. 2004).
Leslie WD & Greenberg ID Nuclear medicine, Landes Bioscience, Georgetown (2003).
Pandit NK Introduction to the pharmaceutical sciences, Lippincott Williams & Wilkins, NY (2006).
Sampson CE Textbook of radiopharmacy theory and practice, Gordon and Breach Science Publishers, NY (3rd ed., 1999).
Tubis M & Wolf W Radiopharmacy, Wiley Interscience, NY (1976).
Tpzer TN & Rowland M - Introduction to Pharmacokinetics and Pharmacodynamics: The Quantitative Basis of Drug Therapy, Lippincott Williams & Wilkins, NY (2006).
Farmacopeia BP, EP, USP;
Teaching method
The unit comprises mandatory practical classes where radio marking, quality control, biodistribution, pharmacokinetics and pharmacodynamics studies are performed.
The unit also includes mandatory seminars taught by specialists in different areas coming from laboratories with which the University of Coimbra collaborates.
Resources used
Laboratório de Medicina Nuclear equipado com gama câmara, calibrador de doses e contador de poço.
Laboratório de Radiofarmácia Quente e Morno.
Laboratório de Experimentação Animal.