Dosimetry of Radiation and Radiobiology - EB

Ano letivo: 2019-2020
Specification sheet

Specific details
course codecycle os studiesacademic semestercredits ECTSteaching language

Learning goals
The deeper understanding of how radiation deposits energy in biological media in the context of use of ionizing radiation in diagnosis and therapy as well as the dosimetric calculation inherent in his use is critical to those who specialize in imaging and radiation. Simultaneously the inherent problems of radiation protection are another related area that requires learning.
The objectives of this course in terms of attitudes, abilities and skills are developing the attitude of methodical research, promote critical observation of measurement procedures, measures and units as well as the associated errors and analysis and synthesis.
Considering the objectives in knowledge: knowing and manipulating the different quantities and units of measure, know the mathematical concepts relating to target's theory in the context of cell irradiation, acquire knowledge about ionizing radiation, its biological effects and dosimetry.
In the first chapter the dosimetric units of the International System as well as the common units are defined. The kinetics associated with cell proliferation and tissue structure are important subjects for the understanding of the subsequent formation of free radicals and the importance of the cytotoxic effects of radiation will taught in the second and third chapters. Some models of cell injury are introduced and the concept of repairable damage and radiosensitivity is explored. The fifth chapter introduces the notion of radiosensitizer and radioprotective giving up convenient examples. With the body of knowledge acquired total body irradiation, the background radiation and radiation protection are themes that are explored in depth. In the laboratory practices the effects of the radiation in cell cultures and its translation into therapeutic terms are observed.
Basic knowledge and competences of Physics and radiations in Biomedicine
Generic skills to reach
. Competence in organization and planning;
. Competence for working in group;
. Competence in working in interdisciplinary teams;
. Ethical commitment;
. Quality concerns;
. Competence in analysis and synthesis;
. Competence to solve problems;
. Competence in interpersonal relations;
. Competence to communicate with people who are not experts in the field;
. Competence in applying theoretical knowledge in practice;
(by decreasing order of importance)
Teaching hours per semester
theory-practical classes22
laboratory classes20
total of teaching hours60

Laboratory or field work30 %
Exam70 %

Bibliography of reference
- Essentials of Radiation Biology and Protection, Steve Forshier, DELMAR Thomson Learning, 2002.
- An Introduction to Radiobiology, A.H.W. Nias, John Wiley and Sons, 2000
- Biological Radiation Effects, Jürgen Kiefer, Springer-Verlag, 1990
- Introduction to Health Physics, Herman Cember, McGraw-Hill, Inc., 1992
Teaching method
The course syllabus is taught in 12h of theoretical (T), 23h theoretical-practical (TP), 40h of laboratory practice (PL) and 5h of seminars (S). At T the matters are taught of expository manner, in TP the students met with new situations, in PL the students perform laboratory work where apply the T and TP knowledge. At seminars each student presents the practical reports and discusses the results obtained.
The teaching team is always available to answer questions.
Resources used